General Information

  • ID:  hor004920
  • Uniprot ID:  P85639
  • Protein name:  Hypertrehalosaemic factor
  • Gene name:  NA
  • Organism:  Gromphadorhina grandidieri (Cockroach)
  • Family:  AKH/HRTH/RPCH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gromphadorhina (genus), Oxyhaloinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QVNFSPGWGT
  • Length:  10
  • Propeptide:  QVNFSPGWGT
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Threonine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Elevate the level of trehalose in the hemolymph
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004920_AF2.pdbhor004920_ESM.pdb

Physical Information

Mass: 125288 Formula: C50H69N13O15
Absent amino acids: ACDEHIKLMRY Common amino acids: G
pI: 6.11 Basic residues: 0
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -48 Boman Index: -692
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 29
Instability Index: 2385 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  19257902
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.